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Mitoketoscins : novel mitochondrial inhibitors for targeting ketone metabolism in cancer stem cells (CSCs)

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Figure

Figure 1: Schematic diagram illustrating our overall drug discovery strategy, employing both in silico and phenotypic drug screening
Figure 8 illustrates the predicted binding sites of the
Figure 5: Quantitation of respiration and ATP production in MCF7 cells treated with compounds 2 (A) and 8 (B)
Figure 8: Docking images of the top 4 hits. Compound 2 docking at the succinyl-CoA binding site of 3-oxoacid CoA-transferase 1 (OXCT1) (Panel A); compound 8 docking at the CoA binding site of human acetyl-CoA acetyltransferase (ACAT1) (Panel B)
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