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PI3K pan-inhibition impairs more efficiently proliferation and survival of T-cell acute lymphoblastic leukemia cell lines when compared to isoform-selective PI3K inhibitors

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Academic year: 2020

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Figure

Figure 1: Inhibition of all the PI3K catalytic isoforms exerts the strongest effects on T-ALL cell line viability
Figure 2: PI3K pan-inhibition impairs proliferation in T-ALL cell lines. Growth curves of T-ALL cell lines treated with 5 μM of PI3K selective and pan-inhibitors counted before treatment (0 h), and after 16, 24, 40, 48, 64 and 72 h of treatment
Figure 3: Expression of PI3K catalytic subunits and PTEN in T-ALL cell lines, and effects of PI3K inhibition on total PIP levels
Figure 4: PI3K pan-inhibition impacts on the PI3K/Akt/mTOR pathway. Cells were cultured for 6 h in the presence of 5 μM of the different PI3K inhibitors, as indicated, and western blot analysis was then performed
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