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NSCLC cells demonstrate differential mode of cell death in response to the combined treatment of radiation and a DNA- PKcs inhibitor

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Figure

Table 1: The tumor growth delay in A549, H460 and H1299 cell lines
Figure 2: NU7441 enhanced cells sensitivity to IR correlates with deficient DSB repair
Figure 3: NU7441 treatment results in a robust G2/M cell arrest in NSCLC cells and specifically leads to checkpoint adaptation in H1299 cells
Figure 4: NU7441 + IR-induces mitotic catastrophe in H1299 cells. (A) H1299 cells were stained with anti-α-tubulin and anti-crest antibodies, the representative images show the normal and aberrant mitosis in H1299 cells
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