• No results found

Brassinin inhibits STAT3 signaling pathway through modulation of PIAS-3 and SOCS-3 expression and sensitizes human lung cancer xenograft in nude mice to paclitaxel

N/A
N/A
Protected

Academic year: 2020

Share "Brassinin inhibits STAT3 signaling pathway through modulation of PIAS-3 and SOCS-3 expression and sensitizes human lung cancer xenograft in nude mice to paclitaxel"

Copied!
20
0
0

Loading.... (view fulltext now)

Full text

Loading

Figure

FIGURE 1: BSN inhibits constitutively active STAT3 in A549 cells. (A) The chemical structure of brassinin (BSN)
FIGURE 2: BSN suppresses the activation of JAK1/2 and Src in a dose-dependent manner. (A) A549 cells (1 × 106 cells/well) were treated with indicated concentrations of BSN, after which whole-cell extracts were prepared and 20 µg portions of those extracts
FIGURE 3: Silencing of PIAS-3 and ectopic expression of SOCS-3 in BSN-treated cells reverse the effect of BSN on STAT3 activation and cell viability
FIGURE 4: BSN suppresses cell proliferation, invasion, and induced apoptosis in A549 cells
+4

References

Related documents

This work suggests that mechanisms not only exist to co-localize MTD to the apoplast with pathogen-produced mannitol, but that other normally cytosolic enzymes that have

La mortalité est en réalité minimisée lorsque la masse corporelle est dans la fourchette de poids élevés-normaux à surpoids et la trajectoire pondérale la plus sécuritaire est

The study finds out that; bursaries from the government are the main source of government community grants, the decision on how to use the grant was made by the school

sepsis lead to plugging of capillaries, resulting in capillary blood flow impairment. 2) Ascorbate lowers platelet aggregation and adhesion by decreasing P-selectin.. expression,

Mehdi Tajdari et al.,[3] had made Surface roughness modeling in hard turning operation of AISI 4140 using CBN cutting tool ,he has to develop Ann model for surface

Three interesting clinical findings were demonstrated and will be discussed as follows: local surgery might be an option for stage IV NSCLC patients; surgery to primary sites

For each example we list the dimension (i.e the number of Sboxes), the achieved branch number and the minimal k such that it is possible to achieve full dependency with two Sbox

If we fail to meet that challenge, our nation can become bankrupt through exhaustion of our usable resources before adequate replace- ments are developed; and