• No results found

Homology Model and Ligand Binding Interactions of the Extracellular Domain of the Human α4β2 Nicotinic Acetylcholine Receptor

N/A
N/A
Protected

Academic year: 2020

Share "Homology Model and Ligand Binding Interactions of the Extracellular Domain of the Human α4β2 Nicotinic Acetylcholine Receptor"

Copied!
60
0
0

Loading.... (view fulltext now)

Full text

Loading

Figure

Figure 1. Study design and overall workflow. BLAST was used to search the human α4β2 nAChR sequence against PDB to select a template sequence for homology modeling
Figure 2. Chemical structures of the eleven compounds in the AChBPs complexes col-lected from PDB and their names used in this paper
Figure 3The final alignment between the template and the target with the secondary structure prediction is shown in dues Y98, W154 and Y195from the These core residues played key roles in the structure-guided mutagenesistween the human aligned well between
Figure 4. Homology model of the human α4β2 nAChR. Template structure Ct-AChBP color coded in red (a) and the homology model is shown in solid blue ribbons for α4 and green ribbons for β2 (b)
+7

References

Related documents

All such charges shall be published and communicated to the International Civil Aviation Organization: provided that, upon representation by an interested contracting State, the

Graphs showing the percentage change in epithelial expression of the pro-apoptotic markers Bad and Bak; the anti-apoptotic marker Bcl-2; the death receptor Fas; the caspase

In conclusion, the finding of this cross-sectional study of pre and post menopausal women show no evidence of a significant difference in BMD between Ocs users and never user

The national health priority areas are disease prevention, mitigation and control; health education, promotion, environmental health and nutrition; governance, coord-

Within the UK, where heroin is almost exclusively smoked or injected, social marketing campaigns and harm reduc- tion materials have previously been developed that aim to

A study conducted on eht reproductive health conditions of 525 male and female adolescents in the Klong Toey slum community in Bangkok, whose average age was 01 ± 2.8 years and

8. Papachristou is the first case in which the United States Supreme Court directly ruled upon the constitutionality of vagrancy laws. Earlier cases dealing with

This study concluded that the Scapular stabilization exercise incorporating early closed kinetic chain exercise were effective in reducing disability and pain in Type 2