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Integrin suppresses neurogenesis and regulates brain tissue assembly in planarian regeneration

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Academic year: 2020

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Fig. 1. βeyes ventrally (7/7 animals). (E,F) Disorganized non-neural tissue generallywas not abundant within spheroids (E; 0/12 spheroids haddiverse lineages (3/7 spheroids had1-integrin inhibition causes formation of ectopic neurospheroidsin planarian hea
Fig. 2. βinhibition produced excess and disorganized tissue. (B)distribution of three brain neuronal subtypes marked by1-integrin suppresses neurogenesis in regeneration
Fig. 3. Global axis patterning is retained following βneurospheroid-related staining evident (6/14 animals).retained expression ofregion, with a slight increase in width along the dorsal anterior midline butotherwise normal medial expression (10/10 animals
Fig. 4. A regeneration delay precedes integrin RNAi tissue disorganization phenotype. (A) Control andsubstantially affect expression ofbrain tissue emerging later (arrows)
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