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Targeting lactate metabolism for cancer therapeutics

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Figure

Figure 1Aerobic glycolysis and glutaminolysis in cancer cells. Oncoproteins drive the expression of genes involved in glycolysis and glutaminolysis, regulate the transcription of GLUT, HK2, TPI, ENO, and LDHA
Figure 2Lactate dehydrogenase activity and tetramers. (NADH. (ing ratios of the LDHA and LDHB subunits
Figure 3Three models of lactate shuttling in cancer. (

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