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Targeting sortilin in immune cells reduces proinflammatory cytokines and atherosclerosis

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Figure

Table 1. Effects of sortilin on plasma cholesterol and atherosclerosis in Apoe–/– mice
Figure 1. Macrophage and Th1 cell function. (flow cytometry as mean fluorescence intensity among 10,000 macrophages from each mouse
Figure 2. Sortilin binds IL-6 and IFN-γadded (200–650 seconds); at 650–1,200 seconds, IL-6, GST-fused sortilin propeptide, or both were added
Figure 3. Sortilin deficiency in immune cells reduces atherosclerosis. (Sort1control A and B) Plasma cholesterol and distribution of cholesterol across size-fractionated lipoprotein classes in male and female BM-transplanted mice

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