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(1)

Tissues

Tissues

(2)

Tissues Tissues

 Cells work together in functionally Cells work together in functionally related groups called tissues

related groups called tissues

 How is this done? How is this done?

 Attachments Attachments

 communication communication

 Types of tissues: Types of tissues:

1. 1. Epithelial – lining and covering Epithelial – lining and covering

2. 2. Connective – support Connective – support

3. 3. Muscle – movement Muscle – movement

4. 4. Nervous – control Nervous – control

(3)

Lateral Surface Features Lateral Surface Features

 Factors holding epithelial cells Factors holding epithelial cells together

together

 Adhesion proteins link plasma Adhesion proteins link plasma membranes of adjacent cells membranes of adjacent cells

 Contours of adjacent cell membranes Contours of adjacent cell membranes

 Special cell junctions Special cell junctions

(4)

Lateral Surface Features Lateral Surface Features

– Cell Junctions – Cell Junctions

 Tight junctions (zona occludens) – Tight junctions (zona occludens) – close off intercellular space

close off intercellular space

 Found at apical region of most epithelial Found at apical region of most epithelial types

types

 Some proteins in plasma membrane of Some proteins in plasma membrane of adjacent cells are fused

adjacent cells are fused

 Prevent molecules from passing Prevent molecules from passing

between cells of epithelial tissue

between cells of epithelial tissue

(5)

Tight Junction

Tight Junction

(6)

Lateral Surface Features – Lateral Surface Features –

Cell Junctions Cell Junctions

 Adherens junctions (zonula Adherens junctions (zonula

adherens) – anchoring junction adherens) – anchoring junction

 Transmembrane linker proteins attach Transmembrane linker proteins attach to actin microfilaments of the

to actin microfilaments of the

cytoskeleton and bind adjacent cells cytoskeleton and bind adjacent cells

 Along with tight junctions, form the Along with tight junctions, form the

tight junctional complex around apical tight junctional complex around apical

lateral borders of epithelial tissues

lateral borders of epithelial tissues

(7)

Zonula Adherens (Belt Zonula Adherens (Belt

Desmosome)

Desmosome)

(8)

Lateral Surface Features Lateral Surface Features

– Cell Junctions – Cell Junctions

 Desmosomes (macula adherens) – Desmosomes (macula adherens) – two disc-like plaques connected two disc-like plaques connected

across intercellular space across intercellular space

 Plaques of adjoining cells are joined by Plaques of adjoining cells are joined by proteins called cadherins

proteins called cadherins

 Proteins interdigitate into extra- Proteins interdigitate into extra- cellular space

cellular space

 Intermediate filaments insert into Intermediate filaments insert into plaques from cytoplasmic side

plaques from cytoplasmic side

CDH1 - E-cadherin (epithelial) CDH2 - N-cadherin (neural)

CDH12 - cadherin 12, type 2 (N-cadherin 2) CDH3 - P-cadherin (placental)

CDH4 - R-cadherin (retinal)

CDH5 - VE-cadherin (vascular endothelial) CDH6 - K-cadherin (kidney)

CDH7 - cadherin 7, type 2 CDH8 - cadherin 8, type 2

CDH9 - cadherin 9, type 2 (T1-cadherin) CDH10 - cadherin 10, type 2 (T2-cadherin) CDH11 - OB-cadherin (osteoblast)

CDH13 - T-cadherin - H-cadherin (heart) CDH15 - M-cadherin (myotubule) CDH16 - KSP-cadherin

CDH17 - LI cadherin (liver-intestine) CDH18 - cadherin 18, type 2 CDH19 - cadherin 19, type 2 CDH20 - cadherin 20, type 2

CDH23 - cadherin 23, (neurosensory epithelium)

(9)

Desmosome Desmosome

Figure 4.7b

(10)

Desmosome Detail

Desmosome Detail

(11)

Lateral Surface Features Lateral Surface Features

– Cell Junctions – Cell Junctions

 Gap junctions – passageway between Gap junctions – passageway between two adjacent cells

two adjacent cells

 Let small molecules move directly Let small molecules move directly between neighboring cells

between neighboring cells

 Cells are connected by hollow cylinders Cells are connected by hollow cylinders of protein

of protein

(12)

Gap Junction Gap Junction

Figure 4.7c

(13)

Epithelial Tissue – Epithelial Tissue –

General Characteristics &

General Characteristics &

Functions Functions

 Covers a body surface or lines a Covers a body surface or lines a body cavity

body cavity

 Forms most glands Forms most glands

 Functions of epithelium Functions of epithelium

 Protection Protection

 Absorption, secretion, and ion transport Absorption, secretion, and ion transport

 Filtration Filtration

 Forms slippery surfaces Forms slippery surfaces

(14)

Special Characteristics Special Characteristics

of Epithelia of Epithelia

 Cellularity Cellularity

cells are in close contact with each other with little or no cells are in close contact with each other with little or no intercellular space between them

intercellular space between them

 Specialized contacts Specialized contacts

may have junctions for both attachment and communicati may have junctions for both attachment and communicati on on

 Polarity Polarity

epithelial tissues always have an apical and basal surface epithelial tissues always have an apical and basal surface

 Support by connective tissue Support by connective tissue

at the basal surface, both the epithelial tissue and the at the basal surface, both the epithelial tissue and the connective tissue contribute to the basement membrane connective tissue contribute to the basement membrane

 Avascular Avascular

nutrients must diffuse nutrients must diffuse

 Innervated Innervated

 Regenerative Regenerative

epithelial tissues have a high capacity for regeneration epithelial tissues have a high capacity for regeneration

(15)

Special Characteristics Special Characteristics

of Epithelia

of Epithelia

(16)

 First name of tissue indicates First name of tissue indicates number of layers

number of layers

 Simple – one layer of cells Simple – one layer of cells

 Stratified – more than one layer of cells Stratified – more than one layer of cells

Classifications of Classifications of

Epithelia

Epithelia

(17)

Classifications of Classifications of

Epithelia Epithelia

 Last name of tissue describes shape Last name of tissue describes shape of cells

of cells

 Squamous – cells wider than Squamous – cells wider than tall (plate or “scale” like)

tall (plate or “scale” like)

 Cuboidal – cells are as wide as Cuboidal – cells are as wide as tall, as in cubes

tall, as in cubes

Columnar – cells are taller than Columnar – cells are taller than

they are wide, like columns

they are wide, like columns

(18)

Naming Epithelia Naming Epithelia

 Naming the epithelia includes both the layers Naming the epithelia includes both the layers (first) and the shape of the cells (second)

(first) and the shape of the cells (second)

 i.e. stratified cuboidal epithelium i.e. stratified cuboidal epithelium

 The name may also include any accessory The name may also include any accessory structures

structures

 Goblet cells Goblet cells

 Cilia Cilia

 Keratin Keratin

 Special epithelial tissues (don’t follow naming Special epithelial tissues (don’t follow naming convention)

convention)

 Psuedostratified Psuedostratified

 Transitional Transitional

(19)

Simple Squamous Simple Squamous

Epithelium Epithelium

 Description Description

 single layer of flat cells with disc-shaped single layer of flat cells with disc-shaped nuclei

nuclei

 Special types Special types

 Endothelium (inner covering) Endothelium (inner covering)

 slick lining of hollow organs slick lining of hollow organs

 Mesothelium (middle covering) Mesothelium (middle covering)

 Lines peritoneal, pleural, and pericardial Lines peritoneal, pleural, and pericardial cavities

cavities

 Covers visceral organs of those cavities Covers visceral organs of those cavities

(20)

Simple Squamous Simple Squamous

Epithelium Epithelium

 Function Function

 Passage of materials by passive diffusion and Passage of materials by passive diffusion and filtration

filtration

 Secretes lubricating substances in serous Secretes lubricating substances in serous membranes

membranes

 Location Location

 Renal corpuscles Renal corpuscles

 Alveoli of lungs Alveoli of lungs

 Lining of heart, blood and lymphatic vessels Lining of heart, blood and lymphatic vessels

 Lining of ventral body cavity (serosae/serous Lining of ventral body cavity (serosae/serous memb.)

memb.)

(21)

Simple Squamous Simple Squamous

Epithelium Epithelium

Simple squamous

lining the walls of the

capillary

If it’s from a

mesothelial lining

(22)

Simple Cuboidal Simple Cuboidal

Epithelium Epithelium

 Description Description

 single layer of cube-like cells with large, single layer of cube-like cells with large, spherical central nuclei

spherical central nuclei

 Function Function

 secretion and absorption secretion and absorption

 Location Location

 kidney tubules, secretory portions of small kidney tubules, secretory portions of small glands, ovary surface

glands, ovary surface

(23)

Simple Cuboidal Simple Cuboidal

Epithelium

Epithelium

(24)

Simple Columnar Simple Columnar

Epithelium Epithelium

 Description Description

 single layer of column-shaped single layer of column-shaped

(rectangular) cells with oval nuclei (rectangular) cells with oval nuclei

 Some bear cilia at their apical surface Some bear cilia at their apical surface

 May contain goblet cells May contain goblet cells

 Function Function

 Absorption; secretion of mucus, Absorption; secretion of mucus, enzymes, and other substances enzymes, and other substances

 Ciliated type propels mucus or Ciliated type propels mucus or

reproductive cells by ciliary action

reproductive cells by ciliary action

(25)

Simple Columnar Simple Columnar

Epithelium Epithelium

 Location Location

 Non-ciliated form Non-ciliated form

 Lines digestive tract, gallbladder, ducts of Lines digestive tract, gallbladder, ducts of some glands

some glands

 Ciliated form Ciliated form

 Lines small bronchi, Lines small bronchi,

uterine tubes, and uterus

uterine tubes, and uterus

(26)

Pseudostratified Pseudostratified

Columnar Epithelium Columnar Epithelium

 Description Description

 All cells originate at basement membrane All cells originate at basement membrane

 Only tall cells reach the apical surface Only tall cells reach the apical surface

 May contain goblet cells and bear cilia May contain goblet cells and bear cilia

 Nuclei lie at varying heights within cells Nuclei lie at varying heights within cells

 Gives false impression of stratification Gives false impression of stratification

 Function Function

 secretion of mucus; propulsion of mucus secretion of mucus; propulsion of mucus by cilia

by cilia

(27)

Pseudostratified Pseudostratified

Columnar Epithelium Columnar Epithelium

 Locations Locations

 Non-ciliated type Non-ciliated type

 Ducts of male Ducts of male

reproductive tubes reproductive tubes

 Ducts of large Ducts of large glands

glands

 Ciliated variety Ciliated variety

 Lines trachea and Lines trachea and most of upper

most of upper

respiratory tract

respiratory tract

(28)

Stratified Epithelia Stratified Epithelia

 Contain two or more layers of cells Contain two or more layers of cells

 Regenerate from below Regenerate from below

 Major role is protection Major role is protection

 Are named according to the Are named according to the shape of shape of cells at apical layer

cells at apical layer

(29)

Stratified Squamous Stratified Squamous

Epithelium Epithelium

 Description Description

 Many layers of cells – squamous in Many layers of cells – squamous in shape

shape

 Deeper layers of cells appear cuboidal Deeper layers of cells appear cuboidal or columnar

or columnar

 Thickest epithelial tissue – adapted for Thickest epithelial tissue – adapted for protection

protection

(30)

Stratified Squamous Stratified Squamous

Epithelium Epithelium

 Specific types Specific types

 Keratinized – contain the protective protein keratin Keratinized – contain the protective protein keratin

Surface cells are dead and full of keratin Surface cells are dead and full of keratin

 Non-keratinized – forms moist lining of body Non-keratinized – forms moist lining of body openings

openings

 Function Function

 Protects underlying tissues in areas subject to Protects underlying tissues in areas subject to abrasion

abrasion

 Location Location

 Keratinized – forms epidermis Keratinized – forms epidermis

 Non-keratinized – forms lining of esophagus, Non-keratinized – forms lining of esophagus, mouth, and vagina

mouth, and vagina

(31)

Stratified Squamous Stratified Squamous

Epithelium Epithelium

Non-keratinized vs.

Keratinized

(32)

Stratified Cuboidal Stratified Cuboidal

Epithelium Epithelium

 Description Description

generally two generally two layers of cube- layers of cube- shaped cells shaped cells

 Function Function

protection protection

 Location Location

Forms largest ducts Forms largest ducts of sweat glands

of sweat glands

Forms ducts of Forms ducts of

mammary glands

mammary glands

and salivary glands

and salivary glands

(33)

Stratified Columnar Stratified Columnar

Epithelium Epithelium

 Description Description

several layers; basal several layers; basal cells usually

cells usually

cuboidal; superficial cuboidal; superficial cells elongated

cells elongated

 Function Function

protection and protection and secretion

secretion

 Location Location

Rare tissue type Rare tissue type

Found in male Found in male urethra and vas urethra and vas deferens, largest deferens, largest ducts of salivary ducts of salivary

glands, nasopharynx

glands, nasopharynx

(34)

Transitional Epithelium Transitional Epithelium

 Description Description

 Basal cells usually cuboidal or columnar Basal cells usually cuboidal or columnar

 Superficial cells dome-shaped or squamous Superficial cells dome-shaped or squamous

 Function Function

 stretches and permits distension of urinary stretches and permits distension of urinary bladder

bladder

 Location Location

 Lines ureters, urinary bladder and part of Lines ureters, urinary bladder and part of urethra

urethra

(35)

Transitional Epithelium Transitional Epithelium

Relaxed state

Stretched

state

(36)

Glandular Epithelium Glandular Epithelium

 Ducts carry products of exocrine Ducts carry products of exocrine glands to epithelial surface

glands to epithelial surface

 Include the following diverse glands Include the following diverse glands

 Mucus-secreting glands Mucus-secreting glands

 Sweat and oil glands Sweat and oil glands

 Salivary glands Salivary glands

 Liver and pancreas Liver and pancreas

 May be: unicellular or multicellular May be: unicellular or multicellular

(37)

Unicellular Exocrine Unicellular Exocrine

Glands Glands

(The Goblet Cell) (The Goblet Cell)

 Goblet cells Goblet cells

produce mucin produce mucin

 Mucin + water Mucin + water   mucus

mucus

 Protects and Protects and

lubricates many lubricates many

internal body internal body

surfaces

surfaces

(38)

Multicellular Exocrine Multicellular Exocrine

Glands Glands

 Have two basic parts Have two basic parts

 Epithelium-walled duct Epithelium-walled duct

 Secretory unit Secretory unit

 Classified by structure of duct Classified by structure of duct

 Simple Simple

 Compound Compound

 Categorized by secretory unit Categorized by secretory unit

 Tubular Tubular

 Alveolar Alveolar

 Tubuloalveolar Tubuloalveolar

(39)

Types of Multicellular Types of Multicellular

Exocrine Glands

Exocrine Glands

(40)

Exocrine Vs. Endocrine Exocrine Vs. Endocrine

Glands Glands

 Endocrine Gland Characteristics: Endocrine Gland Characteristics:

 Ductless glands Ductless glands

 Secrete substances directly into Secrete substances directly into bloodstream

bloodstream

 Produce molecules called hormones Produce molecules called hormones

Which is

Which?

(41)

Basal Feature: The Basal Basal Feature: The Basal

Lamina Lamina

 Noncellular supporting sheet between the epithelium Noncellular supporting sheet between the epithelium and the connective tissue deep to it

and the connective tissue deep to it

 Consists of proteins secreted by the epithelial cells Consists of proteins secreted by the epithelial cells

 Functions: Functions:

Acts as a selective filter, determining which molecules from Acts as a selective filter, determining which molecules from capillaries enter the epithelium

capillaries enter the epithelium

Acts as scaffolding along which regenerating epithelial cells Acts as scaffolding along which regenerating epithelial cells can migrate

can migrate

 Basal lamina and reticular layers of the underlying Basal lamina and reticular layers of the underlying connective tissue form the basement membrane

connective tissue form the basement membrane

 Hemidesmosomal junctions… holding it Hemidesmosomal junctions… holding it all down!

all down!

(42)

Epithelial Surface Epithelial Surface

Features Features

 Apical surface features Apical surface features

 Microvilli – finger-like extensions of Microvilli – finger-like extensions of plasma membrane

plasma membrane

 Abundant in epithelia of small intestine Abundant in epithelia of small intestine and kidney

and kidney

 Maximize surface area across which Maximize surface area across which small molecules enter or leave

small molecules enter or leave

 Act as stiff knobs that resist abrasion Act as stiff knobs that resist abrasion

(43)

Epithelial Surface Epithelial Surface

Features Features

 Apical surface features Apical surface features

 Cilia – whip-like, highly motile Cilia – whip-like, highly motile

extensions of apical surface membranes extensions of apical surface membranes

 Contains a core of nine pairs of Contains a core of nine pairs of

microtubules encircling one middle pair microtubules encircling one middle pair

 Axoneme – a set of microtubules Axoneme – a set of microtubules

 Each pair of microtubules – arranged in a Each pair of microtubules – arranged in a doublet

doublet

 Microtubules in cilia – arranged similarly to Microtubules in cilia – arranged similarly to cytoplasmic organelles called centrioles

cytoplasmic organelles called centrioles

 Movement of cilia – in coordinated waves Movement of cilia – in coordinated waves

(44)

A Cilium

A Cilium

(45)

Connective Tissue Connective Tissue

 Most diverse and abundant tissue Most diverse and abundant tissue

 Main classes Main classes

 Connective tissue proper Connective tissue proper

 Cartilage Cartilage

 Bone tissue Bone tissue

 Blood Blood

 Components of connective tissue: Components of connective tissue:

 Cells (varies according to tissue) Cells (varies according to tissue)

 Matrix Matrix

Fibers (varies according to tissue) Fibers (varies according to tissue)

Ground substance (varies according to tissue) Ground substance (varies according to tissue)

dermatin sulfate, hyaluronic acid, keratin sulfate, dermatin sulfate, hyaluronic acid, keratin sulfate, chondroitin sulfate…

chondroitin sulfate…

 Common embryonic origin – mesenchyme Common embryonic origin – mesenchyme

(46)

Classes of Connective Classes of Connective

Tissue

Tissue

(47)

Connective Tissue Model Connective Tissue Model

 Areolar connective tissue Areolar connective tissue

 Underlies epithelial tissue Underlies epithelial tissue

 Surrounds small nerves and blood vessels Surrounds small nerves and blood vessels

 Has structures and functions shared by other Has structures and functions shared by other connective tissues

connective tissues

 Borders all other tissues in the body Borders all other tissues in the body

 Structures within areolar connective tissue Structures within areolar connective tissue allow:

allow:

 Support and binding of other tissues Support and binding of other tissues

 Holding body fluids Holding body fluids

 Defending body against infection Defending body against infection

 Storing nutrients as fat Storing nutrients as fat

(48)

Connective Tissue Proper Connective Tissue Proper

 Loose Connective Tissue Loose Connective Tissue

 Areolar Areolar

 Reticular Reticular

 Adipose Adipose

 Dense Connective Tissue Dense Connective Tissue

 Regular Regular

 Irregular Irregular

 Elastic Elastic

(49)

Areolar Connective Areolar Connective

Tissue Tissue

 Description Description

Gel-like matrix with: Gel-like matrix with:

all three fiber types (collagen, reticular, elastic) for support all three fiber types (collagen, reticular, elastic) for support

Ground substance is made up by glycoproteins also made and Ground substance is made up by glycoproteins also made and screted by the fibroblasts.

screted by the fibroblasts.

Cells – fibroblasts, macrophages, mast cells, white blood Cells – fibroblasts, macrophages, mast cells, white blood cells

cells

 Function Function

Wraps and cushions organs Wraps and cushions organs

Holds and conveys tissue fluid Holds and conveys tissue fluid

Important role in inflammation Main battlefield in fight Important role in inflammation Main battlefield in fight against infection

against infection

 Defenders gather at infection sites Defenders gather at infection sites

Macrophages Macrophages

Plasma cells Plasma cells

Mast cells Mast cells

Neutrophils, lymphocytes, and eosinophils Neutrophils, lymphocytes, and eosinophils

(50)

Areolar Connective Areolar Connective

Tissue Tissue

 Location Location

 Widely distributed under epithelia Widely distributed under epithelia

 Packages organs Packages organs

 Surrounds capillaries Surrounds capillaries

(51)

Adipose Tissue Adipose Tissue

 Description Description

Closely packed adipocytes Closely packed adipocytes

Have nucleus pushed to Have nucleus pushed to one side by fat droplet one side by fat droplet

Function Function

Provides reserve food fuel Provides reserve food fuel

Insulates against heat loss Insulates against heat loss

Supports and protects Supports and protects organs

organs

 Location Location

Under skin Under skin

Around kidneys Around kidneys

Behind eyeballs, within Behind eyeballs, within

abdomen and in breasts

abdomen and in breasts

(52)

Reticular Connective Reticular Connective

Tissue Tissue

 Description – Description –

network of reticular network of reticular

fibers in loose ground fibers in loose ground

substance substance

 Function – form a Function – form a

soft, internal skeleton soft, internal skeleton

(stroma) – supports (stroma) – supports

other cell types other cell types

 Location – lymphoid Location – lymphoid organs

organs

 Lymph nodes, bone Lymph nodes, bone

marrow, and spleen

marrow, and spleen

(53)

Dense Irregular Dense Irregular Connective Tissue Connective Tissue

 Description Description

Primarily Primarily irregularly irregularly arranged collagen fibers arranged collagen fibers

Some elastic fibers and Some elastic fibers and fibroblasts

fibroblasts

 Function Function

Withstands tension Withstands tension

Provides structural strength Provides structural strength

 Location Location

Dermis of skin Dermis of skin

Submucosa of digestive Submucosa of digestive tract

tract

Fibrous capsules of joints Fibrous capsules of joints and organs

and organs

(54)

Dense Regular Dense Regular Connective Tissue Connective Tissue

 Description Description

 Primarily Primarily parallel parallel collagen fibers collagen fibers

 Fibroblasts and some elastic fibers Fibroblasts and some elastic fibers

 Poorly vascularized Poorly vascularized

 Function Function

 Attaches muscle to bone Attaches muscle to bone

 Attaches bone to bone Attaches bone to bone

 Withstands great stress in Withstands great stress in one direction

one direction

 Location Location

 Tendons and ligaments Tendons and ligaments

 Aponeuroses Aponeuroses

 Fascia around muscles Fascia around muscles

(55)

Cartilage Cartilage

 Characteristics: Characteristics:

 Firm, flexible tissue Firm, flexible tissue

 Contains no blood vessels or nerves Contains no blood vessels or nerves

 Matrix contains up to 80% water Matrix contains up to 80% water

 Cell type – chondrocyte Cell type – chondrocyte

 Types: Types:

 Hyaline Hyaline

 Elastic Elastic

 Fibrocartilage Fibrocartilage

(56)

Hyaline Cartilage Hyaline Cartilage

 Description Description

 Imperceptible collagen fibers (hyaline = Imperceptible collagen fibers (hyaline = glassy)

glassy)

 Chodroblasts produce matrix Chodroblasts produce matrix

 Chondrocytes lie in lacunae Chondrocytes lie in lacunae

 Function Function

 Supports and reinforces Supports and reinforces

 Resilient cushion Resilient cushion

 Resists repetitive stress Resists repetitive stress

(57)

Hyaline Cartilage Hyaline Cartilage

 Location Location

 Fetal skeleton Fetal skeleton

 Ends of long bones Ends of long bones

 Costal cartilage of ribs Costal cartilage of ribs

 Cartilages of nose, Cartilages of nose,

trachea, and larynx

trachea, and larynx

(58)

Elastic Cartilage Elastic Cartilage

 Description Description

 Similar to hyaline cartilage Similar to hyaline cartilage

 More elastic fibers in matrix More elastic fibers in matrix

 Function Function

 Maintains shape of structure Maintains shape of structure

 Allows great flexibility Allows great flexibility

 Location Location

 Supports external ear Supports external ear

 Epiglottis Epiglottis

(59)

Fibrocartilage Fibrocartilage

 Description Description

 Matrix similar, but less firm than hyaline cartilage Matrix similar, but less firm than hyaline cartilage

 Thick collagen fibers predominate Thick collagen fibers predominate

 Function Function

 Tensile strength and ability Tensile strength and ability to absorb compressive

to absorb compressive shock

shock

 Location Location

 Intervertebral discs Intervertebral discs

 Pubic symphysis Pubic symphysis

 Discs of knee joint Discs of knee joint

(60)

Bone Tissue Bone Tissue

 Function Function

 Supports and Supports and protects organs protects organs

 Provides levers and Provides levers and attachment site for attachment site for muscles

muscles

 Stores calcium and Stores calcium and other minerals

other minerals

 Stores fat Stores fat

 Marrow is site for Marrow is site for blood cell formation blood cell formation

 Location Location

 Bones Bones

(61)

Blood Tissue Blood Tissue

 Description Description

 red and white blood cells red and white blood cells in a fluid matrix

in a fluid matrix

 Function Function

 transport of respiratory transport of respiratory

gases, nutrients, and wastes gases, nutrients, and wastes

 Location Location

 within blood vessels within blood vessels

 Characteristics Characteristics

 An atypical connective tissue An atypical connective tissue

 Develops from mesenchyme Develops from mesenchyme

 Consists of cells surrounded by nonliving matrix Consists of cells surrounded by nonliving matrix

(62)

Covering and Lining Covering and Lining

Membranes Membranes

 Combine epithelial tissues and Combine epithelial tissues and connective tissues

connective tissues

 Cover broad areas within body Cover broad areas within body

 Consist of epithelial sheet plus Consist of epithelial sheet plus underlying connective tissue

underlying connective tissue

(63)

Three Types of Three Types of

Membranes Membranes

 Cutaneous membrane – skin Cutaneous membrane – skin

 Mucous membrane Mucous membrane

 Lines hollow organs that open to surface of Lines hollow organs that open to surface of body body

 An epithelial sheet underlain with layer of An epithelial sheet underlain with layer of lamina propria

lamina propria

 Serous membrane – slippery membranes Serous membrane – slippery membranes

 Simple squamous epithelium lying on Simple squamous epithelium lying on areolar connective tissue

areolar connective tissue

 Line closed cavities Line closed cavities

 Pleural, peritoneal, and pericardial cavities Pleural, peritoneal, and pericardial cavities

(64)

Covering and Lining Covering and Lining

Membranes

Membranes

(65)

Covering and Lining Covering and Lining

Membranes

Membranes

(66)

Muscle Tissue Muscle Tissue

 Types Types

 Skeletal muscle tissue Skeletal muscle tissue

 Cardiac muscle tissue Cardiac muscle tissue

 Smooth muscle tissue Smooth muscle tissue

(67)

Skeletal Muscle Tissue Skeletal Muscle Tissue

 Characteristics Characteristics

 Long, cylindrical cells Long, cylindrical cells

 Multinucleate Multinucleate

 Obvious striations Obvious striations

 Function Function

 Voluntary movement Voluntary movement

 Manipulation of Manipulation of environment

environment

 Facial expression Facial expression

 Location Location

 Skeletal muscles attached to bones Skeletal muscles attached to bones (occasionally to skin)

(occasionally to skin)

(68)

Cardiac Muscle Tissue Cardiac Muscle Tissue

 Function Function

 Contracts to propel blood into circulatory Contracts to propel blood into circulatory system

system

 Characteristics Characteristics

 Branching cells Branching cells

 Uninucleate Uninucleate

 Intercalated discs Intercalated discs

 Location Location

 Occurs in walls of heart Occurs in walls of heart

(69)

Smooth Muscle Tissue Smooth Muscle Tissue

 Characteristics Characteristics

 Spindle-shaped cells with Spindle-shaped cells with central nuclei

central nuclei

 Arranged closely to form Arranged closely to form sheets

sheets

 No striations No striations

 Function Function

 Propels substances along Propels substances along internal passageways

internal passageways

 Involuntary control Involuntary control

 Location Location

 Mostly walls of hollow organs Mostly walls of hollow organs

(70)

Nervous Tissue Nervous Tissue

 Function Function

 Transmit electrical signals Transmit electrical signals from sensory receptors to from sensory receptors to

effectors effectors

 Location Location

 Brain, spinal cord, and nerves Brain, spinal cord, and nerves

 Description Description

 Main components are brain, Main components are brain, spinal cord, and nerves

spinal cord, and nerves

 Contains two types of cells Contains two types of cells

Neurons – excitatory cells Neurons – excitatory cells

Supporting cells (neuroglial cells) Supporting cells (neuroglial cells)

(71)

Tissue Response to Tissue Response to

Injury Injury

 Inflammatory response – non- Inflammatory response – non- specific, local response

specific, local response

 Limits damage to injury site Limits damage to injury site

 Immune response – takes longer to Immune response – takes longer to develop and very specific

develop and very specific

 Destroys particular microorganisms at Destroys particular microorganisms at site of infection

site of infection

(72)

The Tissues Throughout The Tissues Throughout

Life Life

 At the end of second month of development: At the end of second month of development:

 Primary tissue types have appeared Primary tissue types have appeared

 Major organs are in place Major organs are in place

 Adulthood Adulthood

 Only a few tissues regenerate Only a few tissues regenerate

 Many tissues still retain populations of stem cells Many tissues still retain populations of stem cells

 With increasing age: With increasing age:

 Epithelia thin Epithelia thin

 Collagen decreases Collagen decreases

 Bones, muscles, and nervous tissue begin to atrophy Bones, muscles, and nervous tissue begin to atrophy

 Poor nutrition and poor circulation – poor health of Poor nutrition and poor circulation – poor health of tissues

tissues

References

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