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Chronic neurodegeneration induces Type I interferon synthesis via STING, shaping microglial phenotype and accelerating disease progression

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Academic year: 2020

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Figure

FIGURE 1Gating strategy and purity of fluorescence-activated cell sorted (FACS) microglia and astrocytes from normal brain homogenate andME7-injected
TABLE 1Quantitative polymerase chain reaction primer and probe sequences
TABLE 2List of antibodies, dilutions, and incubation times
FIGURE 2Type I interferons (IFN-I) response in ME7 prion disease. Hippocampal expression of mRNA for PYHIN proteins (a) p204, (b) cGAS andfor IFN-I and IFN-responsive genes (d) Ifnb1, (e) Irf7, (g) Oas1a, (h) Mx1, (j) Ifnar2, and (k) Eif2ak2 (PKR) in ME7 a
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