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T cells genetically engineered to overcome death signaling enhance adoptive cancer immunotherapy

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Academic year: 2020

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Figure

Figure 1. Human TMEs overexpress the death-inducing ligand FASLG.D27CR7CR7 (A) A pan- cancer analysis of FASLG expression within the microenvironments of 26 different tumor types relative to matched normal tissues of origin
Figure 2. FasL-mediated apoptosis is prevented in T cells engineered with Fas DNRs. (structs or an empty vector control
Figure 3. Enhanced persistence and survival of Fas DNR-engineered T cells in vivo. Transduced Ly5.1in Figure 2B; then 5 × 10total of 8 × 10with the empty or Fasspleens and tumors of recipient mice
Figure 4. Transfer of Fas DNR–modified T cells does not result in acquired ALPS.sublethally irradiated WT mice that received 5 × 10matched WT mice and Fas-deficient B6-lpr mice served as negative and positive controls, respectively
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