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RhoC: a fascinating journey from a cytoskeletal organizer to a Cancer stem cell therapeutic target

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Figure

Fig. 1 Cycling of Ras homolog gene family member C (RhoC) between active and inactive forms: The switching of RhoC between the inactiveGDP-bound form to the active GTP-bound form is regulated by Guanine Nucleotide Exchange Factors (GEFs), GTPase Activating
Table 1 The various signaling pathways in cancer via whichRhoC operates
Fig. 2 An illustration depicting the diverse roles of RhoC in various aspects of cancer progression: RhoC significantly contributes to cancerinitiation, proliferation, stemness maintenance, angiogenesis, invasion, intravasation, and metastasis across numerous tumor models, as shown
Fig. 3 Tumor induction models and the possible role of RhoC: The clonal evolution theory postulates that genetic abnormalities lead to tumorformation, with every clone of cells thus produced being equally capable of regenerating the tumor (a)

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