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Epigenome alterations in aortic valve stenosis and its related left ventricular hypertrophy

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Figure

Fig. 1 Major epigenetics mechanisams acting in mammalian cells. Presented are the four epigenetic mechanisams and their major impact on cellulargene regulation
Fig. 2 Epigenetic mechanisms currently associated with aortic VICs.ERK1mitogen-activated protein kinase 1,SP7 transcription factor/osterix,MMP2beta 1,lipoxygenase,bone morphogenetic protein 2,gene enhancer in b-cells, kinase beta, ALP alkaline phosphatase, liver/bone/kidney, ALOX5 arachidonate 5- AVICs aortic valve interstitial cells, BAV bicuspid aortic valve, BGLAP/OCN bone gamma-carboxyglutamate protein/osteocalcin, BMP2 BMPR2 bone morphogenetic protein receptor type 2, β-catenin CTNNB1/catenin (cadherin-associated protein), CASP3 Caspase 3, apoptosis-related cysteine peptidase, DLX5 distal-less homeobox 5, DNMT3b DNA (Cytosine-5-)-methyltransferase 3 beta, extracellular signal-regulated kinase 1/MAPK3 mitogen-activated protein kinase 3, ERK2 extracellular signal-regulated kinase 2/MAPK1 H19 imprinted maternally expressed non-protein coding transcript, IKKβ inhibitor of kappa light polypeptide NF-Kb nuclear factor kappa b signaling pathway, IGF-1 insulin-like growth factor 1, ILα interleukin alpha, ILβinterleukin beta, IL8 interleukin 8, NOTCH1 notch homolog 1, translocation-associated (drosophila), JAG2 jagged, MMP1 matrix metallopeptidase 1, matrix metallopeptidase 2, MMP9 matrix metallopeptidase 9, MMP14 matrix metallopeptidase 14, MMP16 matrix metallopeptidase 16, OSX p65 RELA/RELA proto-oncogene, NF-KB subunit, RUNX2 runt related transcription factor 2, SMAD1 SMAD familymember 1, SMAD3 SMAD family member 3, SMAD5 SMAD family member 5, SMAD7 SMAD family member 7, SPP1 secreted phosphoprotein 1/OPN osteopontin/BNSP bone sialoprotein I, TGFβ1 transforming growth factor beta 1, TGFBR2 transforming growth factor beta receptor 2, WNT5aWnt family member 5a
Table 1 Genes involved in regulation of epigenetic histone marks and/or chromatin remodeling
Table 1 Genes involved in regulation of epigenetic histone marks and/or chromatin remodeling (Continued)
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