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Noninvasive imaging of the PD-1:PD-L1 immune checkpoint: Embracing nuclear medicine for the benefit of personalized immunotherapy

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Figure

Table 1. Overview of the imaging studies performed in preclinical models.
Figure 1. PD-L1 immunoPET/CT in mice with WT and PD-L1 KO tumors. (A) C57BL/6 mice were subcutaneously injected with 2×10axillary lymph node; BAT: brown adipose tissue; cLN: cervical lymph node; Sp: spleen; Tu KO: PD-L1 KO tumor; Tu WT: wild-type tumor; Ad
Figure 2. SPECT/CT in a PD-L1 KO TC-1 model 1 h after injection of 99m(n=6). periphery of the tumor from PD-L1 KO mice bearing PD-L1 KO tumors (KO, white bars) or WT mice bearing PD-L1tumors injected in PD-L1 KO mice and WT TC-1 cells injected in WT mice,
Figure 3. Schematic representation of the modalities that are currently available to detect PD-1 or PD-L1 expression in tumors, highlighting their advantages (+) and disadvantages (-)
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