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Preventing Radiobleaching of Cyanine Fluorophores Enhances Stability of Nuclear/NIRF Multimodality Imaging Agents

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Figure

Figure 1. Near-infrared fluorescent compounds and radionuclides employed in the study
Figure 2. Photostability of irradiated IRDye 800CW solutions. A) Normalized 800CW fluorescence, 30 min after exposure to increasing activities of 111In, 68Ga, and 213Bi
Figure 3. Radioprotective effects of ˙OH radical scavengers against 68Ga-promoted radiobleaching
Figure 4. A) Structure of four common cyanine dyes: 800CW, Cy7, Cy5.5, and Cy3. B) 68Ga-induced radiobleaching of the dyes in the presence (+) or absence (-) of ascorbic acid (0.1% w/v)
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