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Integrin αvβ8–expressing tumor cells evade host immunity by regulating TGF-β activation in immune cells

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Figure

Figure 1. MC38 colon carcinoma tumor growth in vivo is reduced by anti-αvβ8 and eliminated in the majority of mice by combination with anti–PD-1
Figure 2. Expression of β8 increases in vivo tumor growth. (A) LLC cells were transfected with itgb8
Figure 3. βfields from MC38 tumor edge (panels) or Ki-67 (right panels) and assessed for apoptosis (therapeutically treated with isotype (Iso) or C6D4 (10 mg/kg i.p
Figure 4. The antibody C6D4 decreases CD4+or MHCII low TAM (gating strategy shown in Supplemental Figure 11)as inhuman-specific Shown are representative experiments of at least 3
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