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N -Heterocyclic Carbene-Platinum Complexes Featuring an Anthracenyl Moiety: Anti-Cancer Activity and DNA Interaction.

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Figure

Figure 1. Chemical structures of platinum NHC complexes that show high cytotoxic activities against cancer cells
Figure 2. Molecular structure of the NHC platinum complexes used in this study.
Figure 3. Molecular structure of the platinum complex 1. Selected bond lengths (Å) and angles (°): C(1)-Pt(1), 1.961(1); N(3)-Pt(1), 2.088(3); Pt(1)-I(1), 2.5732(3); Pt(1)-I(2), 2.6013(3); C(1)-Pt(1)-N(3), 174.88(14); C(1)-Pt(1)-I(1); 87.72(10); C(1)-Pt(1)
Table 1. In vitro cytotoxic activity of platinum complex 1 against several cell lines (after 72h of incubation; stock solutions in DMSO for all complexes; stock solution in H2O for cisplatin); values in µM.[a]
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