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Preparation and in vitro and in vivo characterization of cyclosporin A-loaded, PEGylated chitosan-modified, lipid-based nanoparticles

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Academic year: 2020

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Figure

Figure 1 Synthetic scheme for mPEg-CO-(NH-chitosan).Abbreviation: RT, room temperature.
Figure 3 Zeta potential of cyclosporin A-loaded chitosan-modified nanoparticle (left); zeta potential of cyclosporin A-loaded, PEGylated chitosan-modified nanoparticle (right).
Figure 4 In vitro release profiles of cyclosporin A-loaded, PEGylated chitosan-modified nanoparticle () and free cyclosporin A in saturated aqueous solution ().
Table 1 Comparison of pharmacokinetic parameters of cyclosporin A solution, chitosan-modified nanoparticles, and PEGylated chitosan-modified nanoparticles as a two-compartment model after intravenous injection (n = 3–5)
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