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1st Congress of the International Society of Nutrigenetics/Nutrigenomics Hellenic American University/Hellenic American Union

22 Massalias Street Athens, Greece November 11 – 13, 2007

Congress Cochairs

Artemis P. Simopoulos, MD (USA) Raffaele De Caterina, MD, PhD (Italy) Scientific Committee

Raffaele De Caterina, MD, PhD (Italy) Michel de Lorgeril, MD, PhD (France) Serge Ferrari, MD (Switzerland) Steve E. Humphries, PhD (UK) Jing X Kang, MD, PhD (USA) Ronald Krauss, MD (USA) Sergio Muntoni, MD (Italy) Jose Ordovas, PhD (USA)

Marjanne Senekal, PhD (South Africa) Gérard Siest, PhD, PharmD (France) Artemis P. Simopoulos, MD (USA) Lisa Spence, PhD (USA)

Philippa J. Talmud, PhD (UK)

Antonio Velazquez, MD, PhD (Mexico) Nikos Yiannakouris, PhD (Greece) Congress Cosponsors

International Society of Nutrigenetics/Nutrigenomics (ISNN) The Center for Genetics, Nutrition and Health (USA)

Hellenic American University/Hellenic American Union (HAU/HAU, Greece) Harokopio University (Greece)

Belovo – Columbus Concept (Belgium) National Dairy Council (USA)

Nutrilite Health Institute (USA) Nestlé SA (Switzerland) Organized by

International Society of Nutrigenetics/Nutrigenomics The Center for Genetics, Nutrition and Health

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DEDICATION

This congress is dedicated to the “Concept of Positive Health” articulated by Hippocrates 2500 years ago, which is based on the interaction of genetics, diet and physical activity:

'Positive health requires a knowledge of man's primary constitution

(which today we call genetics) and of the powers of various foods, both

those natural to them and those resulting from human skill (today's

processed food). But eating alone is not enough for health. There must

also be exercise, of which the effects must likewise be known. The

combination of these two things makes regimen, when proper attention is

given to the season of the year, the changes of the winds, the age of the

individual and the situation of his home. If there is any deficiency in food

or exercise the body will fall sick.' (5

th

Century BC)

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1st Congress of the International Society of Nutrigenetics/Nutrigenomics Hellenic American University/Hellenic American Union (HAU)

22 Massalias Street Athens, Greece November 11 – 13, 2007

Sunday, November 11, 2007

HAU Auditorium 5:00 – 7:00 p.m. Registration 7:00 – 7:30 p.m. Welcoming Remarks

Artemis P. Simopoulos, President, ISNN Chris Spirou, President, HAU/HAU

Leonidas Koskos, Executive Director, HAU/HAU Nikos Yiannakouris, ISNN, Harokopio University 7:30 – 9:00 p.m. Reception – Hellenic American Union, 8th Floor

Monday, November 12, 2007

HAU Auditorium

7:30 – 8:30 a.m. Registration – Hellenic American Union Plenary Lectures

8:30 – 9:15 a.m. Opening Address:

Nutrigenetics/Nutrigenomics – Nutritional Implications Artemis P. Simopoulos, MD (USA)

9:15 – 10:00 a.m. Nutriepigenomics: A Lifelong Stochastic, Genetic and Environmental Remodeling of our Epigenomes

Claudine Junien, MD (France) 10:00 – 10:30 a.m. Coffee Break

10:30 – 11:00 a.m. Proteomics Strategies and Applications for Nutritional Research

Gilbert S Omenn, MD, PhD (USA) 11:00 – 11:30 a.m. Metabolomics in Health and Disease

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11:30 – 12:00 p.m. Role of Nutrients in Gene Expression – Omega-3 Fatty Acids and the Regulation of Endothelial COX-2

Raffaele De Caterina, MD, PhD (Italy) 12:00 – 2:00 p.m. Lunch and Poster Session

Session I: Genetic Variation and Dietary Response in Cardiovascular Disease Cochairs: Philippa J Talmud, PhD (UK)

Jose Ordovas, PhD (USA)

2:00 – 2:20 p.m. Gene:Environment Interaction on Coronary Heart Disease Risk

Philippa Talmud, PhD (UK)

2:20 – 2:40 p.m. Genetic Variation, Omega-3 Fatty Acids and Heart Disease Jose Ordovas, PhD (USA)

2:40 – 2:50 p.m. A Nutrigenomics Approach to Define a “Lifestyle Algorithm” to be used in Cardiovascular Disease Prevention, Diagnosis and Therapy

Hans-Richard Brattbakk (Norway)

2:50 – 3:00 p.m. Nutriepigenomics of Metabolic Syndrome Ondrej Seda, MD (Czech Republic)

3:00 – 3:15 p.m. Discussion

Discussant: Ronald Krauss, MD (USA) 3:15 – 3:45 p.m. Coffee Break

4:00 – 5:00 p.m. Poster Session – Congress Participants

4:00 – 5:30 p.m. Board of Directors Meeting – ISNN Board Members 5:30 – 6:30 p.m. Business Meeting - ISNN Membership – HAU Auditorium 7:00 – 9:00 p.m. Banquet Buffet – Hellenic American Union, 8th Floor

Tuesday, November 13, 2007

Session II: Gene-Nutrient Interactions and Hypertension Cochairs: Steven C Hunt, PhD (USA)

Steve Humphries, PhD (UK)

8:00 – 8:20 a.m. Dietary Manipulation, Pharmacogenetics, and Genetic Interactions Reveal Defective Genetic Control of Blood Pressure

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8:20 – 8:40 a.m. Variability Genes, Blood Pressure and Coronary Heart Disease Risk

Steve Humphries, PhD (UK) 8:40 – 8:55 a.m. Discussion

Discussant: Steve Humphries, PhD (UK)

8:55 – 9:15 a.m. Special Presentation: Variants in Genes of Metabolic and Signaling Pathways Impacted by Lipid-Based Molecules and Their Association with Age-Related Macular Degeneration John Paul SanGiovanni, ScD (USA)

Sesson III: Gene-Nutrient Interactions and Osteoporosis Cochairs: Serge Ferrari, MD (Italy)

Gerard Siest, PhD, PharmD (France)

9:15 – 9:35 a.m. Bone Mass Regulation by Leptin and Leptin Receptor Polymorphisms

Serge Ferrari, MD (Italy) 9:35 – 9:50 a.m. Discussion

Discussant: Gerard Siest, PhD, PharmD (France)

9:50 – 10:10 a.m. Special Presentation: EUROGENE – eTEN Consortium to Provide Nutrigenetic E-Services

Keith Grimaldi, PhD (UK) 10:10 – 10:40 a.m. Coffee Break

Session IV: Genetics of Obesity Cochairs: Louis Perusse, PhD (Canada)

George Chrousos, MD (Greece)

10:40 – 11:00 a.m. Genetics of Obesity: The Role of Gene-Nutrient Interactions Louis Perusse, PhD (Canada)

11:00 – 11:20 a.m. Anti-inflammatory Diet: Search for Anti-inflammatory Phenotype

Dimiter Dimitrov, MD, PhD (Bulgaria)

11:20 – 11:40 a.m. Predictive Genomics for Determining Genetic Predisposition to Obesity

Marios Kambouris, PhD (Greece)

11:40 – 11:50 a.m. ADIPOQ Gene tagSNP Associations with Serum Adiponectin in Normal Women and Tests of Promoter Activity

Theodosios Kyriakou, MD (UK)

11:50 – 12:00 p.m. Association Between Glutamate Decarboxylase 2 (GAD2) and Binge Eating in Obese Children: Results from the Gendai Study

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12:00 – 12:15 p.m. Discussion

Discussant: George Chrousos, MD (Greece) 12:15 – 2:00 p.m. Lunch and Poster Session

Session V: Genetics of Cancer

Cochairs: Michel de Lorgeril, MD, PhD (France) Antonio Velazquez, MD, PhD (Mexico)

2:00 – 2:20 p.m. Gene-Alcohol Interactions and Cancer Michel de Lorgeril, MD, PhD (France)

2:20 – 2:40 p.m Frontiers in Nutrigenetics/Nutrigenomics at the National Cancer Institute (NCI- NIH)

John A Milner, PhD (USA)

2:40 – 3:00 p.m Genetic Variation, Omega-6 Fatty Acids and Prostate Millie Hughes-Fulford, PhD (USA)

3:00 – 3:15 p.m. Apolipoprotein E (Apo E) Genotypes, Alcohol Consumption and Risk of Sporadic Distal Colorectal Adenomas

Panagiota Mitrou, PhD (UK) 3:15 – 3:30 p.m. Discussion

Discussant: Antonio Velazquez, MD, PhD (Mexico) Session VI: Genetics of Diabetes

Cochairs: Sergio Muntoni, MD (Italy) Jing Kang, MD, PhD (USA) 3:30 – 3:50 p.m Insulin Resistance

Sergio Muntoni, MD (Italy)

3:50 – 4:10 p.m. Association Between the Risk of Type 2 Diabetes and Variants in Genes Involved in Beta-Cell Function and Hepatic Gluconeogenesis in a Chinese Han Population Xu Lin, MD (China)

4:10 – 4:30 p.m. The Effect of Conjugated Linoleic Acid on Gene Expression of Resistin and Adiponectin in Obese Rats Fed With CLA Chang-Hao Sun, PhD (China)

4:30 – 4:45 p.m. Discussion

Discussant: Jing Kang, MD, PhD (USA) 4:45 – 5:00 p.m. Coffee Break

Session VII: Industry and Consumers – What is the Business Model for Personalized Nutrition and Medicine?

Cochairs: Lisa Spence, PhD (USA)

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5:00 – 5:15 p.m. Commercial Nutrigenetic Anti-inflammatory Products Ken Kornman, PhD (USA)

5:15 – 5:30 p.m. The Columbus Concept: a Business Model for Personalized Nutrition & Medicine

Fabien de Meester, PhD (Belgium)

5:30 – 5:45 p.m. An Industry Perspective on Nutrigenomics Laurent B. Fay, PhD (Switzerland)

5:45 – 6:00 p.m. Nutrigenetics & New Market: Customizing Health Care Catia Cale (Portugal)

6:00 – 6:15 p.m. A Case in Commercial Applications of Nutrigenetics Serdar Savas, MD (Turkey)

6:15 – 6:30 p.m. Consumer Perspective on Nutrigenomics Sylvia Rowe, PhD (USA)

6:30 – 6:45 p.m. Discussion

Discussant: Marjanne Senekal, PhD (South Africa) 6:45 – 7:00 p.m. Closing Remarks

Artemis P Simopoulos, MD (USA) Congress Adjourns

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Congress Information

Venue

Hellenic American University/Hellenic American Union 22 Massalias Street

106 80 Athens, Greece Phone: + 30 210 368 0900 Fax: + 30 210 362 1687

Web: www.hau.gr

(Just a few minutes' walk from the PANEPISTIMIO subway station) Abstracts

Deadline for Abstracts to be considered for Oral Presentation was July 31, 2007. However, Abstracts for Poster Presentation will continue to be accepted until September 30th. See instructions on the ISNN website: www.isnn.info

Registration

Registration fee before September 30, 2007 Registration fee ISNN regular member - USD 300 Registration fee ISNN associate member – USD 200 (student, fellow, trainee, technician)

Registration fee ISNN corporate/industry member - USD 400 Registration fee non member* - USD 500

Registration fee after September 30, 2007 Registration fee ISNN regular member - USD 400 Registration fee ISNN associate member – USD 300 (student, fellow, trainee, technician)

Registration fee ISNN corporate/industry member - USD 500 Registration fee non member* - USD 600

* You may join ISNN as a member before registering for the congress – see society website

www.isnn.info to join

Congress registration includes:

ƒ Entry into all scientific sessions

ƒ Program and abstract book

ƒ Lunch, mid-morning and mid-afternoon coffee and tea on all congress days

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Hotel

Please complete the required form found on the ISNN website (www.isnn.infor) and return back

by fax no later than September 30th to:

BEST WESTERN

ESPERIA PALACE HOTEL 22, STADIOU STR. 105 64 ATHENS- GREECE TEL. + 30-210-32 38 000 FAX + 30-210-32 38 100 Http://www.esperiahotel.com.gr E-mail:info@esperiahotel.com.gr

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