• No results found

Hypoxia inducible factor (HIF) as a model for studying inhibition of protein–protein interactions

N/A
N/A
Protected

Academic year: 2019

Share "Hypoxia inducible factor (HIF) as a model for studying inhibition of protein–protein interactions"

Copied!
15
0
0

Loading.... (view fulltext now)

Full text

Loading

Figure

Fig. 1(a) Schematic depicting HIF pathway under normoxic and hypoxic conditions. HIF-1terminal transactivation domain (c) domain structures of HIF-1helix, PASinducible factor 1a – hypoxia inducible factor 1a, HIF-1b – hypoxiab, PHD – prolyl hydroxylase dom
Table 1Summary of the currently available HIF structures
Fig. 2(a) Structure of the heterodimeric HIF-1PDB ID: 1L8C (ii) primary sequence of HIF-1a: ARNT PAS-Bcomplex excised from its ternary complex with DNA (one subunit cyan,one forest green) PDB ID: 4ZPR (b) (i) NMR structure of complexbetween HIF-1a CTAD (cyan) and p300 CH1 domain (forest green)a CTAD with helicalregions indicated.
Fig. 3Modulators of the HIF pathway (a) topotecan and derivative EZN-2208 (b) 2-oxoglutarate (c) DMOG and oxalyl glycine (d) FG-2216(e) roxadustat (f) geldanamycin (g) ganetespib (h) X-ray crystal structure of a hydroxyproline derived inhibitor (orange) bound to pVHL(cyan), PDB ID: 3zrc (i) optimised hydroxyproline derived pVHL inhibitor VH298 (j) echinomycin (k) DNA sequence specific polyamide (l)bortezomib.
+6

References

Related documents

Using a sample of 282 university undergraduate students, the present study investigated the effects of pet ownership on health-related quality of life, whilst

Results: Dynamic contrast- enhanced MRI parameters Ktrans and Kep levels in lesions of NSCLC group were higher than those of benign lesion group; proliferation genes Axin and

We used a phylogenetic, comparative approach to analyse the relationship of degree of tolerance, and of FID in urban and rural populations more directly, to relative sizes of

Therefore, we performed this study to establish the usefulness of serum & ascitic fluid C-reactive protein (CRP) in differential diagnosis of malignant,

Figure 3 Urban vs rural patterns of emergency transport utilization and associated median costs (US$) for women with a preterm labor diagnosis (PTL).. Note: Two hundred fi ve women

From this, defenders of traditional marriage conclude that, if the state seeks to promote the well-being of children, it should confer the status and bene fi ts of civil marriage only

Furthermore, considering the fact that most students are not familiar with the appro- priate study skills and this may probably have a negative bearing on their education and

To accelerate renewable energy service delivery with better quality, comprising various technologies, to households, communities and micro, small and medium sized enterprises in