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Characterizing Functional Domains for TIM-Mediated Enveloped Virus Entry

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Figure

FIG 1 Cytoplasmic and transmembrane domains are nonessential for PVEER activity of TIM proteins
FIG 2 Length of the MLD affects binding of EBOV virions. (A) CLUSTAL V alignment of a region of TIM-1 and mutant MLD amino acid sequences (aa 128 to250 of WT TIM-1)
FIG 3 EBOV transduction correlates with TIM-1 MLD length. (A to C) Transduction of MLD mutant or WT TIM-1-transfected HEK 293T cells with VSVpercent transduction data
FIG 4 Domains of TIM-1 required for PVEER activity can be functionally substituted. (A) The amino acid sequences of TIM-1 MLD switch chimeras are alignedwith the MLD of TIM-1 (aa 128 to 298) (CLUSTAL V)
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