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Increased polymerase fidelity of E89G, a nucleoside analog-resistant variant of human immunodeficiency virus type 1 reverse transcriptase.

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Academic year: 2019

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Figure

FIG. 2. Autoradiogram showing the effect of dNTP concentration on the rateof misinsertion by wild-type (WT) and E89G mutant RTs
TABLE 2. Fold increases in the insertion fidelity of mutant RTs
FIG. 3. Graphic representation of finss of wild-type and E89G RTs. A comparative plot of finss experimentally determined for 11 of the 12 possible mispairs forwild-type and E89G RTs (from Table 1) is shown.

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