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Identification of a single amino acid residue in the capsid protein VP1 of coxsackievirus B4 that determines the virulent phenotype.

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Academic year: 2019

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Figure

FIG. 1.regionsH,(JVBsubclones Genotypes of chimeric coxsackievirus B4 cDNA clones. The top line depicts the structural organization of the coxsackievirus B4 strain) genome (6)
FIG.2.viruses,mericievirusamylaseSerum amylase activity of mice infected with coxsack-B4.B1O.T(6R)micewereinfectedwithparentalstock viruses derived from cDNA clones,or recombinant, viruses and bled from the tail veinchi- at various times p.i
FIG. 3.recombinantB4, Histopathology of pancreatic tissue from B1O.T(6R) mice. Mice were injected intraperitoneally with 104 PFU of coxsackievirus as follows: parental stock virus CB4-P (b), recombinant virus vCB4-P (c), chimeric virus vCB421 (d), parental
FIG. 5.variouswithglucoseneallyDashedconcentration[glucose(2 Change in serum glucose concentrations in mice infected recombinant coxsackieviruses

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