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Inflammasome activation mediates inflammation and outcome in humans and mice with pneumococcal meningitis

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Figure

Figure 1 Median levels of IL-1β (A) and IL-18 (B) with interquartile range by pneumococcal serotype
Figure 2 Expression of NLRP3 and ASC in brain homogenates.of WT,Three mice per group were analysed in the sham infected mice and the 6 hour timepoint; 4 mice were analyzed at the 30 hour timepoint.Data are given as means +/ Expression of NLRP3/GAPDH (A) an
Figure 4 Cytokine levels in blood and brain homogenate. Cytokines were measured in WT (n = 11), Nlrp3−/− (n = 12) and Asc−/− (n = 12)mice in blood (A, C) and brain homogenate (WT; n = 7, Nlrp3−/−; n = 8, Asc−/−; n = 8) (B, D) at 30 hours after induction of
Figure 5 Histopathology in Asc−/−, Nlrp3−/−, and WT mice with pneumococcal meningitis

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