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Supporting shared hypothesis testing in the biomedical domain

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Figure

Fig. 1 Causality hypothesis of TNF alpha overproduction leading to cartilage degeneration and provoking joint deformation
Fig. 2 Refined causality hypothesis of pro-inflammatory factors leading to loss of building blocks of articular cartilage – collagen and proteoglycan –,which in turn lead to cartilage degeneration and provoking joint deformation
Fig. 3 Formalization of knowledge on OA pathogenesis processes
Fig. 4 Our methodology defines a pipeline to transform background knowledge into a hypothesis graph via sequential application of processingof the ontology graphsteps: projection of input Oi ontologies into ontology graphs Gi, assembly of an ontology graph G with input ontology mappings mi, normalization G into a final hypothesis graph H
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