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Recombinant Parainfluenza Virus 5 Expressing Hemagglutinin of Influenza A Virus H5N1 Protected Mice against Lethal Highly Pathogenic Avian Influenza Virus H5N1 Challenge

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Figure

FIG 1 Schematics of recombinant PIV5 expressing H5. (A) Schematics ofrecombinant PIV5 expressing H5N1 HA
FIG 2 Generation and analysis of recombinant PIV5 expressing H5N1 HA between HN and L of the PIV5 genome
FIG 4 Efficacy of rPIV5-H5 against rgVN-PR8 (H5N1) challenge in mice. The mice were inoculated with PBS, PIV5, or ZL48 (n � 10 per group) at a dose of 106PFU per mouse
FIG 6 Analysis of recombinant PIV5 expressing H5N1 HA. (A) Analysis of H5N1 HA expression in cells infected with recombinant PIV5 expressing H5N1 HA.Cells were infected with ZL46, ZL47, and ZL48 as well as PIV5 at an MOI of 1
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