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Heavy Chain-Only IgG2b Llama Antibody Effects Near-Pan HIV-1 Neutralization by Recognizing a CD4-Induced Epitope That Includes Elements of Coreceptor- and CD4-Binding Sites

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Figure

FIG 1 Crystal structure of llama single-domain CD4i antibody JM4 in complex with HIV-1 YU2 gp120 and CD4-mimetic miniprotein M48U1
FIG 2 JM4 epitope on gp120 includes elements of the coreceptor-binding siteand critical elements of the CD4-binding region
FIG 3 Comparison of JM4 epitope with that of other molecules that target the CD4 and coreceptor binding surfaces on gp120
FIG 4 Comparison of per-residue buried gp120 surface area upon binding of JM4 and a set of CD4i and CD4-binding site (CD4bs) antibodies
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