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The Marburg Virus 3′ Noncoding Region Structurally and Functionally Differs from That of Ebola Virus

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Figure

FIG. 2. Results of the chemical modification assay on RNA of the positive-strand minigenome 3M-5MGled to termination of RT
FIG. 3. Chimeric minigenomes between ZEBOV and MARV transcription start signals. (A) Mutational changes to replace the MARV NPtranscription start signal with that of ZEBOV, including the downstream sequence involved in formation of a stable hairpin structu
FIG. 4. Mapping of the MARV 3�are numbered according to their position in the viral RNA
FIG. 5. Characterization of the MARV genomic replication promoter. Various point mutations were introduced into the 3�Huh-T7 cells were transfected with the minigenome system components and analyzed for replication and transcription at 48 h posttransfectio
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