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Dynamics and Heterogeneity of Gene Expression and Epigenetic Regulation at the Single-Cell Level

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Figure 1.1: Cellular states and their dynamics(A) A cellular state is defined by the collection of gene expression states, which determinethe function and phenotype of the cell
Figure 1.2: Cell-cell variability in gene expression levels Cells within a single statecan exhibit variation in gene expression levels due to gene expression noise (left hand side,blue and red arrows indicate variance in each distribution)
Figure 1.3: Lineage specification in early embryonic development
Figure 2.1: Different types of gene expression heterogeneity(A) Intrinsic noise in gene expression can lead to uncorrelated variation (left), while thecoexistence of distinct cellular states can produce correlated variability in gene expression(right)
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