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Construction and Immunological Evaluation of Multivalent Hepatitis B Virus (HBV) Core Virus-Like Particles Carrying HBV and HCV Epitopes

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Figure

FIG. 1. Schematic representation of chimeric HBc�-derived pro-tein-encoding genes constructed in the current work.
FIG. 3. Electron microscopy of purified HBc�(D) HBcHBc-derived VLPs. (A)� without insertions
FIG. 6. Induction of antibodies (Ab) in mice by chimeric HBc�derived VLPs. Shown are antibody titers in pools of sera from fiveanimals at day 14 (A) and at day 28 (B) after the first immunization.Titers in specimens were determined on plates coated with HBc,pre-S1 peptide (20-47), and HCV core protein (1-98) as shown by-different colors.
Figure 9 shows direct measurements of the Th1 cell-derived

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