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Role of glycogen synthase kinase-3β inhibitor AZD1080 in ovarian cancer

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Academic year: 2020

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Figure

Figure 1 effects of aZD1080 on ovarian carcinoma cell proliferation and cell cycle.Notes: (A) MTT cell proliferation assays show that aZD1080 suppressed a2780 and OVcar3 cell proliferation in a concentration-dependent manner
Figure 2 effects of aZD1080 on ovarian carcinoma metastatic ability.Notes: Wound healing assays show that aZD1080 decreased the migration ability of a2780 and OVcar3 cells in a dose-dependent manner
Figure 3 effects of aZD1080 on ovarian carcinoma cell invasion.Notes: Transwell assays show that aZD1080 decreased the invasion ability of a2780 and OVcar3 cells in a dose-dependent manner
Figure 5 mrna and protein expression in aZD1080-treated ovarian carcinoma cells.Notes: aZD1080 exposure reduced the mrna and protein expression of gsK-3β, cDK2, cDK1, cyclin D1, MMP9, and Bcl-xl in ovarian carcinoma cell lines as determined with real-time

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