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Toxicity evaluation of Gd<sub>2</sub>O<sub>3</sub>@SiO<sub>2</sub> nanoparticles prepared by laser ablation in liquid as MRI contrast agents in vivo

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Figure

Figure 1 characterization of the gd-NPs.Notes: TeM micrograph (A) and typical histograms of the size distribution for gd-NPs (B) and thickness of shell (C) as derived from the TeM images (230 particles measured)
Figure 2 (cells of peripheral blood and lymph node, and rOs of neutrophils in peripheral blood, respectively
Figure 3 The half-life, biodistribution, and excretion of the gd-NPs.Notes: (A) half-life was determined by IcP-Ms using blood samples (n=3 at each time point); (B) concentrations of Gd were quantified in the heart, brain, spleen, lung, liver, kidney, and
Figure 5 Representative dynamic contrast-enhanced T1-weighted magnetic resonance images of xenografted tumor after injection of Gd-NPs (15 µmol/kg)

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