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Synthesis and Biological Studies of DNA binding Cyclic Py Im Polyamides

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Figure

Figure 1.1  X-ray crystal structure of double-stranded DNA (PBD 1BNA) and examination of hydrogen bonding between Watson-Crick base pairs
Figure 1.2 X-ray crystal and NMR structures of transcription factor-DNA complexes: TBP (PBD 1TGH), NFB (PBD 1VKX), AR (PBD 1R4I), LEF-1 (PBD 2LEF), Myc/Max (PBD 1NKP), and ETS-1 (PBD 2STW)
Figure 1.3 Chemical structures of DNA-binding natural products: chromomycin A3, actinomycin, calicheamicin oligosaccharide, and distamycin
Figure 1.4 X-ray crystal structures displaying the molecular recognition of DNA by netropsin (PBD 6BNA) and distamycin (PBD 2DND in a 1:1 complex and PBD 378D in a 2:1 complex)
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