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Carbon monoxide-releasing molecule-3 protects against ischemic stroke by suppressing neuroinflammation and alleviating blood-brain barrier disruption

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Academic year: 2020

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Figure

Fig. 1 CORM-3 treatment reduces infarct volume and increases the expression of NeuN and MAP2.brain infarct volume in each group at 24 h ( a, c Representative TTC staining illustrates thea) and 72 h (c) after tMCAO or sham surgery; areas of infarct remain w
Fig. 2 CORM-3 treatment decreased the number of activated microglia at 3 days after ischemia
Fig. 3 Assessments of brain water content and neurologic deficit.24 h ( a, b Quantification of brain water content in the indicated groups ata) and 72 h (b) after tMCAO or sham surgery (*p < 0.05 vs
Fig. 4 Assessment of blood-brain barrier dysfunction.zone at 72 h post-surgery (( a, c Representative brain images show Evans blue leakage at 6 h (a) and 72 h (c) post-surgery ineach group
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