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Increases in p53 expression induce CTGF synthesis by mouse and human hepatocytes and result in liver fibrosis in mice

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Figure

Figure 1Hepatocyte-specific Mdm2-knockout mice show endogenous p53 accumulation, leading to transactivation of p53-regulated genes
Figure 2Hepatocyte-specific Mdm2-knockout mice develop spontaneous liver fibrosis with an increase in expression of the Ctgf gene
Figure 3Hepatocyte-specific
Figure 4Spontaneous liver fibrosis in hepatocyte-specific Mdm2-knockout mice is completely abolished in a hepatocyte-specific p53-knockout back-
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