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A fully human chimeric antigen receptor with potent activity against cancer cells but reduced risk for off-tumor toxicity

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Figure

Figure 1: Generation of folate receptor alpha (αFR)-specific fully human chimeric antigen receptor (CAR) T cells
Figure 2: C4 CAR T cells secrete Th1 proinflammatory cytokine in response to tumor cell line and primary ovarian cancer cell surface associated αFR
Figure 3: Antitumor activity of human T cells expressing C4 CAR in vitro and in vivo. A
Figure 4: Comparison of anti-tumor activity of αFR-specific C4 and MOv19 CARs with CD27 costimulatory endodomain in vitro
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