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Stat3 orchestrates interaction between endothelial and tumor cells and inhibition of Stat3 suppresses brain metastasis of breast cancer cells

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Figure

Figure 1: stat3 activation in breast cancer brain metastases and WP1066 inhibited brain metastasis
Figure 2: Effects of WP1066 on MDA-Mb-231br and bt-474br cells. (A) Cytotoxicity of WP1066 was measured by MTT assay
Figure 3: WP1066 inhibited angiogenesis of MDA-Mb-231br-cell in vivo and in vitro. (A) CD31-positive blood vessels in brain sections from MDA-MB-231BR-cell-injected mice in the vehicle, early WP1066 treatment, and late WP1066 treatment groups
Figure 4: WP1066 inhibited stat3/VEGFr-2 signaling in brain endothelial cells. (A) bEnd.3 cells were transfected with 100 nmol/L siControl or siVEGFR-2 for 48 hours in normal medium (serum free) and conditioned medium of MDA-MB-231BR cells
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