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The Akt1/IL-6/STAT3 pathway regulates growth of lung tumor initiating cells

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Figure 1: Mutant Akt1-E17K increases formation of LCSs. A. Number of primary LCSs generated from control BEAS-2B cells or from the corresponding cells infected with pLenty-Akt1-E17K
Figure 2: Akt1 regulates formation and maintenance of NSCLC LCS. A. Number of primary LCSs generated from NCI-H460 cells or the corresponding cells infected with lentivirus expressing shRNAs to Akt1 (clones #1, #2, #3, respectively)
Figure 3: Akt signalling is required for maintenance of NSCLC LCSs. A. Immunoblot analysis of Akt phosphorylation status in NCI-H460 and PEd/10 cells treated with MK-2206 and LY294002 at the indicated concentrations
Figure 4: Akt1 regulates IL-6 expression in NSCLC cells. A. Relative mRNA expression of IL-6 by Q-RT-PCR in NCI-H460 cells, PEd/10, and derivatives
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