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The matricellular protein CCN1 controls retinal angiogenesis by targeting VEGF, Src homology 2 domain phosphatase 1 and Notch signaling

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Figure

Fig. 1. CCN1 is expressed inendothelial cells in angiogenicvasculature. (A) Analysis of CCN1 andGFP transcript levels of CCN1:GFPreporter transgenic mice during postnataldevelopment of the retinal vasculature.CCN1 and GFP mRNA levels asdetermined by qPCR w
Fig. 2. Retinal vascular abnormalitiesfollowing EC-specific inactivation of theimmunofluorescence images of whole-mounts of retinas of CCN1CCN1 gene
Fig. 3. Loss of CCN1 induces EChyperproliferation. (A) Immunofluorescence
Fig. 4. Loss of CCN1(A,B) Quantification by qPCR of endogenous levels of VEGF-A, VEGF-Band VEGF-C (A) and of VEGF-R1, VEGF-R2 and VEGF-R3 (B) mRNAs inCCN1activation upon endothelial-specificretinas were analyzed by immunoprecipitation with an anti-VEGF-R2
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