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Mutant p53 protects ETS2 from non-canonical COP1/DET1 dependent degradation

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Figure

Figure 1: siRNA screening indicates COP1/DET1 are involved in ETS2 protein stability. (A) ETS2 stability in the absence of candidate ubiquitin ligases
Figure 2: ETS2 amino acids V52, P53 and V308, P309 correspond to COP1 binding motifs required for degradation and interaction
Figure 3: COP1/DET1 aid in the CDK10 mediated degradation of ETS2. Degradation of ETS2 wild-type and alanine mutants by COP1/DET1 and CDK10
Figure 4: ETS2 alanine mutants for CDK10 phosphorylation sites are less susceptible to CDK10 mediated degradation
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