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Dynamic ploidy changes drive fluconazole resistance in human cryptococcal meningitis

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Figure

Figure 1. Flowchart of patients recruited to the clinical observational study. Patients in cohort 1 received induction treatment as per local treatment policy, either 800 mg or 1200 mg per day FLC for the first 2 weeks
Figure 2. Phenotypes of tolerance and heteroresistance. Cnsmaller and more translucent at 16 mg/l
Figure 3. Heteroresistance is a continuous variable
Figure 4. FLC monotherapy causes an increase in the resistant subpopulation in patient CSF, which can be prevented by the addition of 5FC
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