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Using a genetically encoded sensor to identify inhibitors of Toxoplasma gondii Ca2+ Signalling

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Figure

FIGURE 1. Zaprinast raises cytosolic Caat 400 s, as indicated.thapsigargin at 100 s (calcium over 20 s following the addition of each drug
FIGURE 2. Compound screen identifies modulators of zaprinast-induced Ca2� signaling. A, GCaMP5-expressing parasites pretreated with Cpd2 or avehicle control were stimulated with zaprinast or a vehicle control, and fluorescence was measured to determine a Z
FIGURE 3. PKG inhibitors display distinct modes of inhibition. A, activity of recombinant PKG in the presence of increasing concentrations of Inh1, Inh2, orthe PKG inhibitor Cpd2
FIGURE 4. Enh1 and Enh2 mobilize intracellular Ca100and treated with 102� stores. A, GCaMP6-expressing parasites suspended in buffer supplemented with either extracel-lular (1 mM) or basal (100 nM) Ca2� concentrations, with or without 1% FBS, �M Enh1 or En
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