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HIV antibody complexes enhance production of type I interferon by plasmacytoid dendritic cells

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Figure

Figure 2. pDCs utilize TLR7, IRF7, IRF5, NF-κfor 15 hours per cell and were then permeabilized and stained for (p-IRF7
Figure 3. HIV Ab specificity regulates type I IFN production by pDCs. HIVBaL was cultured with (A) anti-gp120 Abs that interfere with CD4 binding (B12, PG9, PG16, and VRC01) or with an anti-gp120 Ab that does not interfere with CD4-binding (2G12), (B) VRC0
Figure 4. HIV-immune complexes that do not interfere with CD4 binding specifically enhance IFN-α production by pDCs while suppressive mAbs block production of multiple cytokines
Figure 5. IFN enhancement by HIV-specific Abs requires CD4 and CCR5 binding and IRF7/NF-B
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