Negative feedback regulation of the ERK1/2 MAPK pathway
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![Fig. 2 ERK1/2 MAPK signalling in response to different oncogenicstimuli. a In cells with mutation or amplification of upstreamcomponents [e.g., RTKs (1)] and expressing wild-type Raf proteins,negative feedback mechanisms are highly active (2,3) and signifi-c](https://thumb-us.123doks.com/thumbv2/123dok_us/9474308.453768/11.595.116.291.60.244/signalling-different-oncogenicstimuli-amplication-upstreamcomponents-expressing-feedback-mechanisms.webp)
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