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What have we learned from BeSt?

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Figure

Fig. 1. Flow diagram of the treatment strategies, showing required treatment intensification steps as long as three-monthly measured DAS remained N2.4
Fig. 3. Patient disposition over time (observed data, showing the percentage of total number of patients included, not of total number of patients with data available at that timepoint) for patients allocated to (A) sequential monotherapy, (B) step-up comb
Fig. 4. Percentages of patients on various treatment steps over time for patients allocated to (A) sequential monotherapy, (B) step-up combination therapy, (C) initial combination with prednisone and (D) initial combination with infliximab
Fig. 6. Estimated radiographic damage (weighted generalized estimating equation), during/after ten years of targeted treatment, with multiple medication adjustments when low disease activity was not achieved or maintained, for the four treatment strategies

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