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Rapid determination of aminoglycosides in pharmaceutical preparations by electrospray ionization mass spectrometry

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Figure

Fig. 1 Positive-ion MS1 electrospray-ionization spectra acquired froma sample of gentamicin (a), tobramycin (b), and amikacin (c) underlow-energy in-source fragmentation conditions (declusteringpotential 50 V)
Fig. 2 Precursor-ion spectrum acquired for m/z 322 from a solution of gentamicin (a), and those for m/z 324 and 425 from solutions oftobramycin (b) and amikacin (c), respectively
Fig. 3 Product-ion spectra of m/z 478 (a), m/z 464 (b), and m/z 450 (c) acquired from ions generated from a solution of gentamicin
Table 1 Summary of flow-injection analysis single-ion monitoring (FIA-SIM) method versus the internal standard method
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