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Metabolic profiling of triple-negative breast cancer cells reveals metabolic vulnerabilities

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Figure

Fig. 1 Metabolomics profiling of TNBC cell lines. Hierarchical clustering of metabolic profiles of TNBC cell lines reveals molecular heterogeneityratios of metabolite concentrations in conditions INC280/vehicle and erlotinib/vehicle are plotted for each se
Fig. 2 TNBC basal metabolic profiles.cprior to measuring OCR. OCR values were normalized to total cell numbers for each cell line in the OCR assay
Fig. 3 TNBC maximal metabolic profiles.was measured twice in the basal state, and then twice again following each metabolic inhibitor treatment (1ECAR values were normalized to a measurement of total cell numbers for each cell line in the ECAR assay
Fig. 4 TNBC response to metabolic modulators.bmetformin, and 1 mM AICAR. Data are viability averages from one representative experiment with error bars representing SD
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