Magnetic Resonance Techniques in Multiple Sclerosis

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Magnetic Resonance Techniques

in Multiple Sclerosis

Eighteenth Advanced Course

SCIENTIFIC PROGRAM

CME ACCREDITED COURSE

Milan, 19-20 March 2015

San Raffaele Scientific Institute Via Olgettina, 60 - 20132 Milano, Italy

Neuroimaging Research Unit

Institute of Experimental Neurology, Division of Neuroscience,

San Raffaele Scientific Institute and Vita - Salute San Raffaele University

Università Vita-Salute

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ORGANIZING SECRETARIAT

Biomedia srl – Monica Arosio Via L. Temolo 4 – 20126 Milano Tel. 02/45498282 - Fax 02/45498199

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Magnetic Resonance Techniques in Multiple Sclerosis - Eighteenth Advanced Course

Milan, 19-20 March 2015 1

Maria P. Amato (Firenze, Italy) John Ashburner (London, UK) Marco Battaglini (Siena, Italy) Ralph Benedict (Buffalo, USA) Giancarlo Comi (Milan, Italy) John De Luca (West Orange, USA)

Nicola De Stefano (Siena, Italy) Christian Enzinger (Graz, Austria)

Arman Eshaghi (Teheran, Iran) Monica Falautano (Milan, Italy)

Massimo Filippi (Milan, Italy) Jeroen J. Geurts (Amsterdam, Netherlands)

Roland Henry (San Francisco, USA) Mark A. Horsfield (Leicester, UK)

Mark Jenkinson (Oxford, UK) Carsten Lukas (Bochum, Germany)

Maria A. Rocca (Milan, Italy) James Sumowski (West Orange, USA)

Koen Van Leemput (Boston, USA) Alex P. Zijdenbos (Montreal, Canada)

FACULTY MEMBERS

MAGNETIC RESONANCE TECHNIQUES

IN MULTIPLE SCLEROSIS

Eighteenth Advanced Course Milan, 19-20 March 2015 SCIENTIFIC DIRECTION: M. Filippi G. Comi SCIENTIFIC SECRETARIAT: M.A. Rocca ORGANIZING SECRETARIAT: G. Nyitrai L. Zonca

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Programme

19 March 2015

09.00-09.15 Welcome, introductory remarks

G. Comi

09.15-09.30 Program overview

M. Filippi

Atrophy quantification in MS: from clinical needs to methodological pitfalls. Towards the identification of the best method?

SESSION I - THE CLINICAL PERSPECTIVE

Chairs: M. Filippi, G. Comi

09.30-10.00 What structures should be measured? Whole brain vs WM/GM segmentation?

N. De Stefano

10.00-10.30 Deep GM nuclei: a simple, clinically meaningful measure?

R. Benedict

10.30-11.00 Spinal cord atrophy: the missing measure?

C. Lukas

11.00-11.30 Coffee break

SESSION II - METHODOLOGICAL CONSIDERATIONS

Chairs: N. De Stefano, R. Henry

11.30-12.00 How to measure: accuracy, reproducibility, sensitivity to changes

M.A. Horsfield

12.00-12.30 T1 lesion refilling: how and why?

M. Battaglini

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Magnetic Resonance Techniques in Multiple Sclerosis - Eighteenth Advanced Course

Milan, 19-20 March 2015 3

Programme

SESSION III - METHODS AND SOFTWARES: CROSS-SECTIONAL AND LONGITUDINAL APPLICATIONS, PROS AND CONS I

Chairs: M.A. Rocca, A. Eshaghi

13.30-14.00 FSL: SIENA, SIENAx, FIRST

M. Jenkinson 14.00-14.30 SPM J. Ashburner 14.30-15.00 Freesurfer K.V. Leemput 15.00-15.30 Afternoon tea

SESSION IV - METHODS AND SOFTWARES: CROSS-SECTIONAL AND LONGITUDINAL APPLICATIONS, PROS AND CONS II

Chairs: R. Benedict, M.A. Horsfield

15.30-16.00 CIVET

A.P. Zijdenbos

16.00-16.30 ANTs

A. Eshaghi

16.30-17.00 How to choose a method and its implementation

R. Henry

17.00-18.00 SESSION V - ROUND TABLE SUMMING UP AND CONCLUSIONS

Chair: M. Filippi

Discussants: N. De Stefano, R. Benedict, C. Lukas, M.A. Horsfield, R. Henry

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20 March 2015

Imaging cognitive dysfunction in MS

SESSION VI - THE CLINICAL PERSPECTIVE

Chairs: M. Falautano, J. Sumowski

9.00-9.15 Introduction

G. Comi

9.15-9.45 Neuropsychological profiles in MS: from cognitive relapse to dementia

J. De Luca

9.45-10.15 Cognitive assessment: towards a unified evaluation

M.P. Amato

10.15-10.45 Coffee break

SESSION VII - THE IMAGING PERSPECTIVE

Chairs: J. De Luca, M.P. Amato

10.45-11.15 WM lesions and damage: just a disconnection syndrome?

C. Enzinger

11.15-11.45 GM lesions and damage: do they explain the whole story?

J.J. Geurts

11.45-12.15 Plasticity: what is the evidence?

M.A. Rocca

12.15-12.45 Brain reserve and cognitive reserve: where are we going?

J. Sumowski

12.45-13.15 Concluding remarks

M. Filippi

13.15-14.30 Farewell cocktail

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Magnetic Resonance Techniques in Multiple Sclerosis - Eighteenth Advanced Course

Milan, 19-20 March 2015 5

General Information

REGISTRATION

Registration is free and includes admission to scientific sessions, conference materials, coffee breaks, lunch and certificate of attendance.

HOW TO REGISTER

All participants are kindly recommended to register via the online registration form at www.biome-dia.net

CONTINUING MEDICAL EDUCATION (ECM only for Italian participants)

The event addresses to the disciplines of Neurology, Neurophysiopathology, Neuroradiology. In order to obtain credits, participants must attend the full educational programme (100% of the meeting) and pass the final learning test available on line on the site www.providerecm.it.

CERTIFICATE OF ATTENDANCE

A certificate of attendance will be available to each participant at the end of the meeting

OFFICIAL LANGUAGE

English. Simultaneous translation service is not provided.

HOTEL ACCOMMODATION

In case of accomodation please contact: Biomedia Travel di Biomedia srl Via L. Temolo, 4 – 20126 Milano

Tel.: 02/45498282 - Fax: 02/45498199 - e-mail: biomediatravel@biomedia.net

CONGRESS VENUE

San Raffaele Scientific Institute - Aula San Raffaele (c/o Direzione Sanitaria) Via Olgettina, 60 - 20132 Milano, Italy

HOW TO REACH THE VENUE

 Motorways: San Raffaele Congress Centre can be reached by all motorways, following the direc-tion "Tangenziale Est" (East ring road) till Cascina Gobba exit.

 Subway: San Raffaele Congress Centre is connected to Milan by green subway line. The subway stop is Cascina Gobba.

 Railway: Milano Central Railway Station is connected to San Raffaele Congress Centre by subway (green line).

 Airports: Malpensa Airport (50 km) and Linate Airport (5km) are connected to San Raffaele Congress Centre by railway, bus or taxi.

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Magnetic Resonance Techniques

in Multiple Sclerosis

Eighteenth Advanced Course

Milan, 19-20 March 2015

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