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High drug-loading nanomedicines: progress, current status, and prospects

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Figure 1 Preparation and temperature-dependent working mechanism of the cationic, thermosensitive, copolymer-capped MSNPs.Abbreviations: MSNPs, mesoporous silica nanoparticles; NIPAAm, N-isopropy-lacrylamide; BvIm, butyl vinylimidazolium.
Figure 2 Synthesis, drug loading, and surface modification of MCNPs.Abbreviations: MCNPs, mesoporous carbon nanoparticles; DSPe, 1,2-distearoyl-sn-glycero-3-phosphoethanolamine; mPeG, methoxy polyethylene glycol; oMCNs, oxidized mesoporous carbon nanospheres; Dox, doxorubicin; PeG, polyethylene glycol.
Figure 3 Dox encapsulation in HMCNCs and pH-stimulated release of Dox from folate–HMCNC-Dox.Abbreviations: Dox, doxorubicin; HMCNC, hollow magnetic colloidal nanocrystal; PAA, polyacrylic acid.
Figure 4 Formation of absorption/desorption-type MOF-based nanomedicine and MBioF-type nanomedicine by coordination-directed self-assembly processes.Abbreviations: MOF, metal–organic framework; MBioF, metal–biomolecule framework.
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