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MicroRNA-645 targets urokinase plasminogen activator and decreases the invasive growth of MDA-MB-231 triple-negative breast cancer cells

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Figure

Figure 1 The expression of uPa in breast cancer cells.Notes: Breast cancer cells McF-7, Zr75-1, BT474, sK-Br3 and MDa-MB-231 were cultured and harvested for western blot experiments
Figure 3 infection with lV-645 inhibited uPa expression and the in vitro cleaving of pro-MMP-9 protein.Notes: (A) MDa-MB-231 cells that had been infected with control mirna, lV-645 or lV645+ uPaMut were harvested for iP experiments
Figure 4 lV-645 inhibited MDa-MB-231 subcutaneous growth in nude mice.Notes: MDa-MB-231 cells that had been infected with control mirna, lV-645 or lV-645+ uPaMut were seeded into nude mice to form subcutaneous tumors
Figure 5 lV-645 inhibited the in vitro invasion and migration of MDa-MB-231 cells.Notes: MDa-MB-231 cells that had been infected with control mirna, lV-645 or lV-645+ uPaMut were measured by transwell experiments for in vitro invasion (A) or in vitro migra
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